3 最后，在没有任何其他干预的情况下，测量Cellulize LED 532nm绿光对橘皮组织的效果，作为研究的一部分。Nurnberger-Muller量表(NMS)，一个作为行业标准的四级量表，用于划分橘皮组织的阶段或程度，并确定治疗干预后橘皮组织阶段或程度的变化，以确保一致的评价标准。来自活性设备以及安慰剂的结果均显示，受试者在接受一次532nm绿光治疗后，大腿/臀部的橘皮组织，总体上没有减少。这一结果未能达到预期的主要结果衡量标准，即以Nurnberger-Muller量表(NMS)衡量大腿/臀部的橘皮组织外观从基线到治疗完成后的减少。
FDA产品分类代码OLI，有一份指导文件是该产品的特殊控制，即Guidance for Industry and FDA Staff↪Zs_200A↩-↪Zs_200A↩Class II Special Controls Guidance Document。用于美容的低级激光系统。根 据该指导文件，FDA认为，当特殊控制与一般控制相结合时，将足以为用于美容的低水平激光系统的安全性和有效性提供合理保证。Cellulize符合特殊控制共识标准中概述的所有标准。
Duarte FO, et al.Can low-level laser therapy (LLLT) associated with an aerobic plus resistance training change the cardiometabolic risk in obese women?A placebo-controlled clinical trial.J Photochem Photobiol B. 2015 Dec;153:103-10.
da Silveira Campos RM, Dâmaso AR, et al.The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women.Lasers in Medical Science.2018 Aug;33(6):1245-1254.
We talk a lot about cardiac health. After all, heart disease is the #1 killer of women in the United States. Everyone needs to be aware of cardiovascular diseases and how to protect themselves as best they can. As a culture, we also talk a lot about skin health – slathering on sunscreen as part of our daily routine and supplementing our diets with collagen-boosting foods. Weight loss, inflammation, memory, GI health, and how an unhealthy diet and lack of exercise can prematurely age you – these are all at the forefront of our minds. But how often do we think about the health of our bones?
A decrease in bone health creeps up on you and most people are unaware of how bone density changes over time. Roughly up until the age of 30, men and women actually build more bone than they lose, so we are constantly strengthening our bones and working on bone density. But when we hit our mid-30s, things change. And if you’ve passed that benchmark, you may have felt that shift.
After reaching their mid-30s, women lose about 2% of bone density every year, and that continues for a few years following menopause. This leaves women with a high likelihood of experiencing osteoporosis.
So what do you do? Consider trying OsteoStrong, a non-pharmaceutical way of improving bone density, strength, and balance as one of your biohacking techniques.
According to OsteoStrong’s website, research indicates that the stimulus required to activate the growth of healthy bone tissue is 4.2 multiples of body weight. However, this level of force would be exceptionally difficult to achieve on your own. That’s why OsteoStrong utilizes the Spectrum System, which is part of a new category of devices called the Robotic Musculoskeletal Development System (RDMS).
Biohacking Tip 4: Gratitude
How we view life has a huge effect on our moods, how we treat others, and our general levels of fulfillment. When you have an abundance mindset, you’re consistently grateful for everything that comes your way and is always focused on the positive. Have a hard time adopting this type of perspective? Changing your mindset is really about nothing more than practice. You need to consistently refocus your brain to see the positive in every situation until it becomes second nature. These biohacking techniques and tools can help:
A gratitude journal in which you write three to five things you’re grateful for helps you reframe the day to focus on the positive and reflect on all the good things that happen to you.
Take a gratitude walk where you give thanks and send positive energy to every living thing you see. If you walk to work or take a morning jog, you can easily incorporate this into your normal routine.
Write a weekly letter of gratitude to someone who has helped you or who means a lot to you. It could be a family member, a long-lost friend, or even a coworker who always remembers to stock your favorite coffee.
Begin the day with a ritual, such as meditating, and set an intention to be grateful for all you encounter.
Biohacking Tip 5: Supplements
Exercising, eating right, and developing the right mindset are important steps tounlocking an extraordinary life. Biohacking helps you take this to the next level by incorporating supplements that improve focus, increase energy, and help your body benefit from the most bioavailable forms of nutrients available.
We often don’t get all the vitamins and minerals we need to keep us at peak performance. High-quality supplements in the form of pills, shakes, bars, or drinks can fill the nutritional gap and help boost performance, detoxify our systems, and achieve daily energy.
Tony has created a variety of health supplements, drinks, and bars that help you feel your best every day and make biohacking the body easy.
We live in a 24-hour environment, in which light and darkness follow a diurnal pattern. Our circadian pacemaker, the suprachiasmatic nuclei (SCN) in the hypothalamus, is entrained to the 24-hour solar day via a pathway from the retina and synchronizes our internal biological rhythms. Once we come to this world, one of the first things we need, is food. Naturally, as mammals(from Latin mamma “breast”), we feed ourselves from the breast. But, Human breast milk is more than a meal — it’s also a clock, providing time-of-day information to infants. The composition of breast milk changes across the day, giving energizing morning milk a different cocktail of ingredients than soothing evening milk. Researchers believe this “chrononutrition” may help program infants’ emerging circadian biology, the internal timekeeper that allows babies to distinguish day from night.
What happens, though, when babies drink milk that does not come directly from the breast but is pumped at different times of the day and stored in advance of feeding? Scientists have rarely considered the potential effects of “mistimed” milk on infants’ development, but the implications are potentially far-reaching.
In the same way, rhythmic variations in ambient illumination impact behaviors such as rest during sleep and activity during wakefulness as well as their underlying biological processes. The availability of artificial light has substantially changed the light environment, especially during the evening and night hours. Phones, laptops, ipads, and more around the babies. This may increase the risk of developing circadian rhythm sleep-wake disorders (CRSWD), which are often caused by a misalignment of endogenous circadian rhythms and external light-dark cycles. On the other hand, light can also be used as an effective and non-invasive therapeutic option with little to no side effects, to improve sleep, mood, and general well-being.
The architecture of the circadian system
The central master-clock in mammalian species is a paired structure in the hypothalamus with a volume of just about 0.25 mm3 per nucleus. Within the mammalian SCN, a molecular oscillator keeps the clock oscillating at its normal pace. The basis of this oscillator is two interconnected molecular feedback loops of clock gene expression, a detailed description of which is beyond the scope of this review though.
Successful interaction between body and environment however needs more than just a central clock; it also requires input pathways relaying information about the environment and the body to the SCN to achieve adequate entrainment as well as output pathways communicating timing information to the body to synchronize bodily processes with the circadian phase
Sleep, eating, and energy levels all show circadian rhythms, which means they follow a daily cycle. As any parent who has sleepwalked through a 3 a.m. feeding knows, infants are not born with these rhythms fully set. Instead, their sense of day and night develops over the first weeks and months of life, thanks to cues like sunlight and darkness.
Babies vary: Some show predictable circadian fluctuations in hormones linked with alertness, sleep, and appetite, and can sleep for long stretches shortly after birth, whereas others seem to have their daily rhythms upside-down for months. Delays in the development of circadian biology can increase the risk of colic and lead to growth and feeding problems.
Breast milk may help program infant circadian rhythms, helping to explain why some parents of newborns enjoy long full nights of sleep, whereas others struggle to get their infants on a schedule.
Breast milk changes dramatically over the course of the day. For example, levels of cortisol — a hormone that promotes alertness — are three times higher in morning milk than in evening milk. Melatonin, which promotes sleep and digestion, can barely be detected in daytime milk, but rises in the evening and peaks around midnight.
Night milk also contains higher levels of certain DNA building blocks which help promote healthy sleep. Day milk, by contrast, has more activity-promoting amino acids than night milk. Iron in milk peaks at around noon; vitamin E peaks in the evening. Minerals like magnesium, zinc, potassium, and sodium are all highest in the morning.
Daytime milk may pack a special immune punch. Among mothers who provided researchers with milk samples across the first month postpartum, immune components — including key antibodies and white blood cells — looked higher in day milk compared to night milk. Another study found higher levels of a component important for immune system communication in day milk compared to night milk.
While it’s clear that milk changes over the course of the day, scientists know little about what this means for infant health. Researchers do know that the hormones and immune components in breast milk are passed along to infants and that infants are starting to develop and refine their own circadian rhythms during the first months of life. It’s plausible that the chronosignals in breast milk would help to shape infants’ own circadian biology. Differences in infant feeding patterns might help explain why there’s such variability in the development of these daily rhythms from one infant to another.
Fundamentals of light
To understand the effects of light on human physiology, it is important to understand light. Briefly, light is radiation in a specific range of the electromagnetic spectrum.
The spectrum of daylight, which is light from the sun filtered by the atmosphere is relatively broadband in its distribution. The availability of daylight depends on geographical location and season. In the timeframe of human evolution, it is a rather recent development that light can be available during all times of day through artificial light. Artificial light allows for illuminating indoor and outdoor spaces. It comes in many forms, e.g. incandescent, fluorescent, or light-emitting diode (LED) lighting.
While light generated by these technologies may all appear “white”, the underlying spectra are rather different.
The reason why many different types of spectra might have the same appearance lies in the retina. Critically, different spectra, even if they create the same visual impression, may vary in their chronobiological effects on the circadian clock.
Recently, the Commission International de l’Eclairage (CIE), the international standard body for quantities related to light, issued a new standard containing a reference framework for quantifying the effects of light on non-visual functions.
Effects of LED light on the circadian clock
Two effects of light have been interrogated extensively in human circadian and sleep research: (1) the acute suppression of melatonin in response to light exposure and (2) the ability of light exposure to shift circadian phase.
The system mediating melatonin suppression has a spectral sensitivity that is broadly consistent with the spectral sensitivity of melanopsin. Similarly, the spectral sensitivity of circadian phase-shifting shows its maximal effect near the peak spectral sensitivity of melanopsin.
The effects of light on the phase of the circadian clock depend on the timing of light exposure. This is formally summarised in the phase response curve (PRC), which describes the amount of phase shift (in minutes and hours) achieved by exposure of light at a given circadian phase. Roughly speaking, the effect of morning light is that it advances the clock, while evening and night light delays the clock.
Both melatonin suppression and circadian phase shifts are modulated by the “photic history”, i.e. the amount of light seen during the day. The long-term adaptive influences of the “spectral diet” in the real world remain an important area of investigation.
Effects of light on sleep
The human sleep-wake cycle, which is periods of sleep during the night and wakefulness during the day, is one of the most prominent examples of a circadian behavioral pattern, especially for babies. It results from the interaction between two factors: the circadian drive for wakefulness and the homeostatic sleep pressure. The activity of the circadian pacemaker is aligned to counteract the increasing sleep pressure resulting from sustained wakefulness during the daytime. Likewise, the nocturnal increase in circadian sleep tendency counteracts the decrease in sleep propensity resulting from accumulated sleep thereby supporting a consolidated phase of nocturnal sleep.
Breast milk, artificial lighting, smartphones, and visual display units
In addition to natural daylight, babies are nowadays also exposed to a considerable amount of artificial light. This is particularly the case in the evening hours, i.e. when the circadian system is most sensitive to light-induced phase delays. Thereby, light therapy is more efficient to delay the timing of the circadian clock and thus sleep.
Even thou, mothers can label their milk with the time it was pumped and coordinate infant feedings to offer morning milk in the morning, afternoon milk in the afternoon, and night milk at night, they keep the constant use of visual units around the baby. The use for the babies is not different, entertainment as well
So, which one is better?
Is always about finding the balance. Rather than only use one of the methods, the responsible practice of light therapy and adequate alimentation of your newborn should be combined to get on track the circadian system
We’ve all been in the search to help us achieve perfect skin. But is it just a dream, or can it really be achieved? It looks like having light shined on your face may be the most important part of your skin routine.
Red light’s anti-inflammatory and collagen-building effects on the skin have been documented for years, showing its healing abilities. However, light therapy is branching out, including other light spectrums such as green, blue, purple, and amber, for different healing abilities.
Ellen Marmur, a New York dermatologist, said, It has just enough variety that people stay excited to use it.” While many at-home devices are small and require multiple treatments to cover the entire face, masks help solve this issue.
“It makes people feel good, like they’re taking care of themselves,” Dr. Marmur said. “You can treat your skin while doing other things, so it’s easier to form the habit of doing it every day.”
So How Does LED Work?
LED therapy, known as photobiomodulation, can alter biological matter using varying wavelengths of light.
Jared Jagdeo, associate professor of dermatology and director of the Center for Phototherapy, SUNY Downstate Health Science University, studies LED therapy. “You can alter the skin through photo-damaging with lasers, or photobiomodulation, which is a much more gentle way of changing the way the skin functions,” he said.
When asked why red light works particularly well with skin, he said, “There’s a specific receptor in the mitochondria of the skin cells that red light specifically acts upon. And that’s why red light is an ideal wavelength for changing the way the skin functions.”
Red light can pass through the skin, deeply entering tissue and stimulating the cell’s mitochondria, which results in anti-inflammation and the skin’s rejuvenation. Collagen is also produced in the dermis, smoothing out wrinkles and plumping the skin.
While blue light doesn’t penetrate deeply into the skin, it kills acne-causing bacteria on the skin’s surface. Green light, on the other hand, focuses on melanocytes, reducing excess melanin production.
Brain S. Biesman, assistant clinical professor of ophthalmology, dermatology, and ENT at Vanderbilt University Medical Center in Nashville, states that most red light therapy devices aren’t powerful enough to cause eye damage. “Just normal blinking and eye movements should be sufficient to protect the eyes,” he said. “But never stare at a bright light source.”
“As far as the F.D.A. is concerned, if I use CO2 laser resurfacing, it better work because of the amount of risk involved,” said Suzanne Kilmer, a clinical professor of dermatology at the UC Davis School of Medicine in Sacramento and director of the Laser and Skin Surgery Medical Group.
“Compare that to a home device,” Dr. Kilmer said. “If it doesn’t kill you, blind you or make things much worse, it’s probably going to get approved. So it’s actually more incumbent upon the people selling home devices to show efficacy. You have to trust the people who are selling them.”
“LED is real, but it’s probably not optimized yet,” Dr. Kilmer said.
With light therapy, various factors help determine the amount of light your skin needs: the light’s strength, the distance from the skin, the length of time the device is used on the skin, and the natural color of your skin.
“Some of these lights on the market are very weak, and they may not have enough energy output to actually have a biological effect,” Dr. Jagdeo said. “Imagine a glow stick. It produces a color. But you could shine it on your face all day, and it’s not going to change the way your skin works.”
Moreover, the medical community hasn’t determined the standardized dose for treating skin conditions such as hyperpigmentation and acne at home. Dr. Marmur chose her MMSphere dosing on Blu-U, an in-office blue light typically used as an alternative therapy for precancerous lesions.
“Consistent Sphere treatment for seven weeks will equal the energy given in the office with the Blu-U,” she said.
Another device, the Dr. Dennis Gross DRx SpectraLite FaceWare Pro, $435, releases red and blue light in a mask format, with each session lasting only three minutes. The mask’s LEDs are in contact with the skin, which may be a more effective treatment.
Dr. Jagdeo said, “This is a tremendously undertapped area in medicine. But LED light therapy is going to revolutionize the way home medical treatment is delivered for skin care over the next 10 to 15 years.”
If you’re considering developing your own LED facial mask, at Kayian Medical, our team of experts knows what they’re doing. We developed the Aduro mask, the top facial mask in the beauty industry with celebrities such as Julia Robert fans of the Aduro Mask. For more information, visit https://www.aduroled.com/.
Migraine is a neurological condition that can cause multiple symptoms. It’s frequently characterized by intense, debilitating headaches. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraines often run in families and affect all ages.
People describe migraine pain as:
Migraine symptoms may begin one to two days before the headache itself. This is known as the prodrome stage. Symptoms during this stage can include:
Fatigue or low energy
LED Green Light: a Novel, Non-Invasive, and Non-Pharmacological Therapy.
The effects of green light on the brain have been researched and well-documented for years. The green light can reset the circadian rhythm through melatonin, the hormone that regulates our sleep-wake cycles. A special photoreceptor system in the human eye picks up light and elicits non-visual responses, sending signals to the brain to reset the body’s internal clock and altering melatonin production levels.
Long-time sufferers of migraines and other chronic pain conditions may benefit from exposure to LED green light. A new study, led by pharmacologist Mohab M. Ibrahim, M.D., Ph.D., found that the color green may be key to easing pain.
Ibrahim’s interest in studying the ameliorating effects of green light was inspired by his brother, who has dealt with severe headaches for several years. Instead of taking ibuprofen, his brother would sit in his garden and soak up the verdure of nature to ease the pain from his headaches.
“I wanted to see what is in his garden or in a garden, in general, that would make headaches better,” said Ibrahim, director of the Chronic Pain Management Clinic at Banner — University Medical Center Tucson.
In his clinical practice, Ibrahim also saw that his patients suffering from migraines and fibromyalgia had limited treatment options, and wanted to find a novel, non-invasive, nonpharmacological therapy.
In his study, which has yet to be published, Ibrahim exposed 25 migraine volunteers first to white lights for two hours as a control, then to green LED lights. He measured multiple parameters, including pain reduction, frequency of migraines or headaches, frequency of fibromyalgia flare-ups, pain intensity and duration, and quality of life.
On a scale of 0 to 10, with 0 indicating no pain and 10 the highest level of pain, migraine volunteers had an initial average baseline pain score of 8. After completing the green light therapy, their score dropped down to an average of 2.8. The frequency of headaches dropped from 19 to 6.5 per month, and the overall quality of life climbed from 48 percent to 78 percent.
“The best part about it … is the simplicity, the affordability and, most importantly, the lack of side effects,” Ibrahim said. “It’s a normal light. We’re not using a high-energy laser or anything like that.”
But if pain works through the nervous system, how exactly can green light, which works through the visual system, make people feel better?
New studies show that there are neuronal connections that span from the retina all the way to the spinal cord, passing through the parts of the brain that control and modulate pain. Green light changes the levels of serotonin and alters the endogenous opioid system, an innate pain-relieving system found throughout the central and peripheral nervous system, gastrointestinal tract, and immune system, said Bing Liao, M.D., a neurologist at Houston Methodist Hospital.
“The endogenous opioid system … allows the body to generate something similar to opioids and gives us a sensation of pain relief and happy feeling,” Liao said. “Research has found that, with green light, the receptors of the endogenous opioid system can increase production in the brain and body, and the hormone by itself can increase in production, as well. … It might be an explanation for why people feel good when they’re in a green environment.”
While more studies must be done to test the efficacy of green light therapy as a treatment for chronic pain, Ibrahim said he is trying to advance this therapy as a complement to current therapies.
“What this green light therapy offers is a non-invasive, non-pharmacological additional tool, so it might help reduce opioids,” he said. “I don’t think it will eliminate opioids, but at least it may reduce it enough. It may provide people just with extra help or extra relief so that they may not need the number of opioids that they’re on.”
Now, you don’t often hear about cats getting depressed. In fact, most people don’t even know if depression is possible in animals.
A typical morning for cats usually involves purring, meowing, and stretching alongside family members. Then they’ll go to their favorite place to settle down in, and you continue with your day.
While we become comfortable with our cat’s daily routine, do we actually know our feline pets? What if your cat is depressed? Could you understand why? How can you help your cat overcome winter blues?
Cats are extremely sensitive to changes in light, more than humans. If there’s less light, a decrease in brain chemicals, including serotonin, can occur. When the weather changes to rain or snow, it’s not unusual for cats to feel the shift in sunlight.
Your cat, whether indoor or outdoor, may become depressed during the winter months. The lack of sunlight, less physical activity, and more time alone can contribute to feelings of restlessness or seasonal affective disorder (SAD).
What causes SAD?
SAD in felines occurs similar to humans, and it’s highly influenced by the amount of sunlight they’re exposed to daily.
If your cat has SAD, you may notice them behaving gloomy and moving slower than usual during the winter. However, when April and May roll around, they have more energy and appear happier.
The lack of sunlight is a serious problem as it reduces melatonin production, which results in depression, lethargicness, and anxiety. It also creates low levels of serotonin which acts as a neurotransmitter. With low serotonin, your cat may show signs of aggression, mood swings, and depression.
Achieving chemical balance is not easy, especially since serotonin cannot be given in a shot or pill. While your vet may prescribe a serotonin reuptake inhibitor (SRI), it comes with its side effects. A natural and non-invasive treatment option is light therapy, which adds natural sunlight into your cat’s environment to restore their chemical balance.
Using light therapy to treat SAD
You’ll often heart veterinarians recommend light therapy as a treatment for SAD. Light therapy is an affordable, natural, and non-invasive treatment option that can help stabilize your animal’s emotional highs and lows. And it costs less than a year’s supply of pet food.
At Kaiyan Medical, we recommend treating your animal for 30 minutes every day with red light therapy. Cat and dogs suffer from many conditions such as inflammation, arthritis, and infections. Light therapy gives you the chance to help treat your pet and reduce their pain and suffering.
How it works
How does red light therapy actually help to treat animals? While you may think the answer is complex, it’s not. Red light therapy delivers red and infrared light into the animal’s cells, boosting the body’s natural ability to heal.
Using either LEDs or LASER diodes, light penetrates through the skin, entering the body’s cells. Photoreceptors in your animal’s cells absorb the light’s energy, enhancing the natural healing process by stimulating the cells’ energy production.
The use of varying lights helps treat different areas of the body. For example, red light is easily absorbed by tissue rich in hemoglobin, helping to heal surface wounds.
Near-infrared light penetrated into deeper tissues within the body, entering muscles, joints, bones, tendons, and ligaments for extensive treatment. Combing red, green, and near-infrared light offers a well-rounded treatment for your animal.
What else light therapy can do for your cat?
The way light therapy stimulates cells can help treat several conditions in animals, including:
Clinical data has supported and proven light therapy’s effectiveness in treating animals. In one study, horses suffering from chronic back pain responded to red light therapy in less than three months of therapy, with 70% gaining the ability to train and compete. Other studies have also proven that horses treated with red light therapy experience faster tissue healing times.
If you’re considering treating your dog or cat with light therapy, the first thing you need to do is consult your veterinarian, ensuring it’s the right treatment option for your pet.
Light therapy treats various conditions; however, if your pet is experiencing severe SAD, they may need an extensive treatment plan. At Kayian Medical, we love our animals and want to provide them with the best support possible.
Low-Intensity Light Therapy: Exploring the Role of Redox Mechanisms. Joseph Tafur, M.D. and Paul J. Mills, Ph.D.
Effect of NASA light-emitting diode irradiation on wound healing. J Clin Laser Med Surg. 2001
Treatment of chronic back pain in horses. Stimulation of acupuncture points with a low-powered infrared laser. Martin BB Jr. 1987.
Equine wound healing: influence of low-level laser therapy on an equine metacarpal wound healing model. Jann. 2012.
Effect of light-emitting diode (LED) therapy on the development of osteoarthritis (OA) in a rabbit model. Biomed Pharmacother. 2011
Low-level laser therapy reduces time to ambulation in dogs after hemilaminectomy: a preliminary study. Draper WE. 2012
Researcher fighting breast cancer with light therapy
"Metastatic breast cancer can be a devastating diagnosis with high rates of relapse and death, and there are currently no effective therapies,"
Nalinikanth Kotagiri, MD, Ph.D. says.
"Despite newer treatments, many patients still succumb to the disease. Major limitations include acquired resistance to therapies and serious side effects from treatment. Due to the widespread location of breast cancer cells, particularly in the bone marrow, which harbors the tumor cells as well as vital stem cells, the risk of toxicity is even higher with conventional therapies. Therefore, new therapeutic strategies that selectively destroy tumor cells, increase treatment efficacy, prevent relapse and reduce side effects by sparing the healthy stem cells are necessary."
This is why Nalinikanth Kotagiri, MD, Ph.D., assistant professor in the James L. Winkle College of Pharmacy and a cluster hire for the Cincinnati Cancer Center, is hoping to study ways ultraviolet light can activate light-sensitive drugs to treat this invasive breast cancer and provide that light at the end of the tunnel patients yearn for.
Kotagiri has been awarded the Department of Defense Breast Cancer Breakthrough Award—over $600,000 for three years—to try to do just that. His project will focus on light-mediated therapies, which could activate light-sensitive drugs to target only the cancerous cells.
"Therapies such as photodynamic therapy (PDT), involving light and a photosensitizing chemical substance, which used in conjunction with molecular oxygen can cause cell death, offer a high degree of control that is effectively used to manage cancer in early to advanced stages," he says. "It operates on a simple principle where a light-sensitive drug, which is otherwise nontoxic, introduced into certain tissues can cause cell death when activated by light. Despite the promise of PDT, it can't penetrate tissue deeply so its use is limited. Also, current light-sensitive drugs require oxygen to be effective, but many tumors, including breast tumors, have pockets of low oxygen or grow in regions where oxygen is either low or absent, which could prevent effective application of PDT in cancer treatment."
However, Kotagiri says recent work in the lab has led his team to a "two-pronged approach" in addressing these issues.
"We've been using ultraviolet (UV) light from radionuclides (radioactive nuclide or atom), which are already used to image tumors and tissues, and tried to solve oxygen dependence by using metal-based light-sensitive drugs for depth- and oxygen-independent PDT," he says. "By replacing the external light source, such as lasers and lamps, with light from radionuclides as an 'internal' light source, we've been able to better control therapy in the body.
"This could mean more effective therapies with minimal toxicity to vital organs and tissues. Since radionuclides are used in imaging and locating tumors, we can now simultaneously image and treat breast cancer metastasis using the same radionuclide."
Using animal models, researchers in Kotagiri's lab will test whether radionuclide light activation of tumor targeting, light-sensitive drugs will destroy metastatic cancer cells—including those that are resistant to traditional therapies.
"Since how we're killing the cells is not dependent on a certain molecular pathway, the technology could be applicable to treat a wide variety of breast cancers," he adds. "This has the potential to be a common image-guided treatment strategy to treat patients in early as well as advanced stages of the disease, and because of the safety of this treatment strategy, it could be effectively used alongside other treatments, like chemotherapy and immunotherapy, without the risk of additional side effects.
"This could tremendously benefit patients, as it could potentially improve therapeutic outcomes in addition to setting a precedent to tailor other FDA-approved light-sensitive drugs as radionuclide activated therapies, expanding the scope and range of the diseases these drugs currently treat. If proven beneficial, this treatment could be ready for a patient population in 5 to 10 years, since all the materials involved have already been used in humans—this could be an exciting breakthrough."
Clinical Trial - The Effects of Light Therapy to Treat Cancer-related Side Effects
ClinicalTrials.gov Identifier: NCT04418856
Besides what Kotagiri said, severe fatigue, depression, sleep problems and cognitive impairment are the most commonly reported side effects of cancer treatment. These aversive side effects are hypothesized to be related to the disruption of circadian rhythms associated with cancer and its treatment. Exposure to Bright White Light (BWL) has been found to synchronize the circadian activity rhythms but research with cancer patients has been scarce. Therefore, the proposed randomized control trial (RCT) will test if systematic light exposure (sLE) will minimize overall levels of cancer-related fatigue (CRF), depression, sleep problems and cognitive impairment among breast cancer patients undergoing breast cancer treatment (i.e., surgery, chemotherapy). SLE incorporates the delivery of harmless UV-protected BWL or Dim White Light (DWL - standard comparison in light studies) delivered to patients by using special glasses for 30 minutes each morning, during their treatment.
Like any other organ or part of the human body, the brain, too, is susceptible to injuries or declining functions, especially as we grow older. A healthy diet, physical exercise, and improving your blood pressure, blood sugar, or blood cholesterol levels are some of the ways through which you can maintain a healthier, younger brain.
The brain can suffer from numerous disorders that can be divided into:
Traumatic events such as stroke, traumatic brain injury, and global brain ischemia.
Aging-related degenerative diseases like Alzheimer’s, Parkinson’s or dementia.
Psychiatric and mood disorders, including schizophrenia, anxiety, and depression.
Mentally stimulating activities are vital to keeping the brain young. Different brain activities, such as solving puzzles, math problems, or anything that may require at least some cognitive effort, contributes to the maintenance of the brain’s neural plasticity.
Neural plasticity is the ability of the central nervous system (CNS) to adapt to changes in the environment, aging, trauma, or injuries. It’s an important brain process in which neural networks work together to build a more resilient nervous system and maintain its proper functioning.
Improved reaction Time, Memory, and Mood
The first placebo-controlled study to demonstrate some of the benefits of Light Therapy treatments on the human brain was performed in 2013. Multiple improvements were observed among participants who received Light Therapy compared to the placebo group. Light therapy participants experienced:
Quicker reaction time, proved with the sustained-attention psychomotor vigilance task (PVT) that measured the speed by which study participants responded to visual stimulus.
Better memory, proved by the delayed match-to-sample (DMS) memory task, where the outcome measures included measuring readiness for a quick response and the number of correct trials.
Improved mood, as Light Therapy helped participants to sustain more positive emotional states. The mood was measured by the Positive and Negative Affect Schedule (PANAS), a clinical survey that measures feelings and emotions. The participants were asked to fill the form in before and two weeks after having a treatment.
Light Therapy against Cognitive Decline
In a more recent study effort, researchers treated older adults who were at risk of cognitive decline with Light Therapy. A positive neurocognitive effect was observed among the participants in this study, all of whom aged between 49 and 90. Some of the participants also struggled with cognitive decline due to vascular disease, however, Light Therapy was effective regardless of the nature of their cognitive decline.
As Light Therapy helped the elderly participants boost cognitive scores, researchers on the team were also able to observe their increased brain waves power (alpha, beta, and gamma brain waves in their resting state).
Combating age-related cognitive decline with Light Therapy has been in the focus of another recent study, published in February 2019. This study examined the frontal brain functions among elderly men. Frontal brain functions are key to directing behavior. The participants were divided into two groups, treatment, and placebo. Those who received treatment indeed showed improved cognitive performance following the treatment. These results demonstrate that Light Therapy can really work in a safe manner to treat age-related cognitive decline.
Light Therapy and Executive Function
As of 2017, we also know that Light Therapy can improve the brain’s executive function. This is your ability to manage time, pay attention, change focus, plan, organize, multitask, remember details, or avoid saying the wrong thing at the wrong time3. In other words, the ability to create and meet goals.
As research further suggests, Light Therapy helped study participants to better perform in the Wisconsin Card Sorting Task (WCST)4. This is a neurophysiological test where the task-takers are asked to match a set of cards presented to them, in an attempt to assess their ability to demonstrate cognitive flexibility–a key process in cognitive ability. They are not told how to match the cards, but only if their particular match is correct or not. The WCST is a clinical way to measure the brain’s executive function. Those participants who received Light Therapy made fewer errors on the task and demonstrated improved set-shifting ability compared to the control group.
Such results suggest that Light Therapy improves the brain’s executive function and may have intriguing potentials for treating or preventing deficits resulting both from aging or neuropsychological disorders which include conditions such as epilepsy, stroke, migraines, brain tumors, dementia, multiple sclerosis, Parkinson’s and Alzheimer’s among others.
Can Light Therapy Improve Your Ability to Learn?
In 2017, scientists tested 118 people to see if Light Therapy can have a meaningful impact on their learning abilities. In a similar fashion to previous research, the participants were divided into treatment and placebo groups. Light Therapy showed that the treatment group improved their learning capabilities.
During the trial, the Light Therapy device was directed at the lateral prefrontal cortex of participants, and following treatments, they experienced faster and better rule-based learning5. So, imagine having all participants been bartenders demanded to know the exact ingredients of Mojito, Bloody Mary, Margarita, and other essential cocktails. This Light Therapy treatment would have aided their ability to remember all the ingredients needed for fashioning each drink, adding each ingredient in the desired sequence, or remember who on the table ordered a stronger Bloody Mary. We demonstrate this type of ability through our brain’s rule-based learning capacity.
Different life events may inhibit our brain’s ability to learn. Aging certainly is one of them. Other reasons may include extended exposures to pesticides or neurotoxins, which impair the mitochondria in brain cells. Since Light Therapy kind of “exercises” the mitochondria and prompts the brain to forge new neural networks, the process itself acts as a cognitive rehabilitation6. Which also leads us to the next section.
Light Therapy and Traumatic Brain Injuries
Cognitive decline may occur due to traumatic brain injuries, too. A person who suffers from one may face memory or concentration problems, mood swings, depression, anxiety, or speech problems among other TBI manifestations. What gives hope is another batch of studies that attests to the positive cognitive benefits among TBI patients from receiving Light Therapy.
Light Therapy has been shown to stimulate the growth of new nerve tissue and synapses in damaged brain cells, thus improving the cognitive brain functions of those patients who not only suffer from TBI but also from Chronic traumatic encephalopathy (CTE). The latter is a degenerative brain disease prevalent among athletes and military veterans or anyone who presents with a history of repetitive brain trauma.
Using light therapy to eradicate addictive behaviors in rats.
They targeted light in the prelimbic region of the brain in rats who were addicted to cocaine. They found that after exposure to light therapy the rats demonstrated a significant reduction in addictive behavior.
The lead author of the study, Antonello Bonci, MD, scientific director of the intramural research program at the NIH’s National Institute on Drug Abuse (NIDA), said: “When we turn on a laser light in the prelimbic region of the prefrontal cortex, the compulsive cocaine seeking is gone.”
The study, published in Nature, highlights the role that the prefrontal cortex has in cocaine addiction and could help drive further testing in humans.
As one of the major health concerns in the U.S., cocaine addiction affects close to 1.2 million Americans and is responsible for a total of 482,188 emergency room visits every year.
One of the main problems with cocaine addiction is that people start taking the drug compulsively and lose the ability to function without it. About 80 percent of people who try to kick their cocaine addiction end up experiencing a relapse within six months.
Rats that were addicted to cocaine expressed low patterns of activity in their prefrontal cortex region of the brain – responsible for decision-making and behavioral flexibility.
Previous studies conducted on humans compulsively addicted to cocaine have found a similar pattern of low activity in this area of the brain as well.
The researchers measured the impact that laser light had on brain activity and addiction using a technique called optogenetics.
Through the use of genetic engineering they inserted proteins called rhodopsins into neurons located in the prefrontal cortex of rats. By activating this region of the brain with the laser they were able to turn the nerve cells on and off.
They observed that after turning the cells on there was a significant reduction in addictive behaviors in the rats compared to when the cells were turned off.
Among humans, the therapy would likely not involve the use of lasers, but instead the use of electromagnetic stimulation outside the scalp, with a technique called transcranial magnetic stimulation (TMS).
A common beta blocker, propranolol, currently used to treat people with hypertension and anxiety, has shown to be effective in preventing the brain from retrieving memories associated with cocaine use in animal-addiction models, according to Devin Mueller, UWM assistant professor of psychology and a co-author with James Otis of the research.
"Right now, there are no FDA-approved medications that are known to successfully treat cocaine abuse," says Mueller, "only those that are used to treat the symptoms of cocaine withdrawal, which are largely ineffective at preventing relapse."
The effects of propranolol were long-lasting and could be permanent, he says, even without subsequent doses and even in the presence of stimuli known to induce relapse.
Post-traumatic stress disorder (PTSD) is a mental health condition that’s triggered by a terrifying event — either experiencing it or witnessing it. Symptoms may include flashbacks, nightmares, and severe anxiety, as well as uncontrollable thoughts about the event.
Most people who go through traumatic events may have temporary difficulty adjusting and coping, but with time and good self-care, they usually get better. If the symptoms get worse, last for months or even years, and interfere with your day-to-day functioning, you may have PTSD.
Getting effective treatment after PTSD symptoms develop can be critical to reduce symptoms and improve function.
PTSD symptoms are generally grouped into four types: intrusive memories, avoidance, negative changes in thinking and mood, and changes in physical and emotional reactions. Symptoms can vary over time or vary from person to person
The Light Helper, the EMDR Therapy
Eye Movement Desensitization and Reprocessing (EMDR) therapy is an interactive psychotherapy technique used to relieve psychological stress. It is an effective treatment for trauma and post-traumatic stress disorder (PTSD).
During EMDR therapy sessions, you relive traumatic or triggering experiences in brief doses while the therapist directs your eye movements.
EMDR is thought to be effective because recalling distressing events is often less emotionally upsetting when your attention is diverted. This allows you to be exposed to the memories or thoughts without having a strong psychological response.
Over time, this technique is believed to lessen the impact that the memories or thoughts have on you.
What are the Benefits of EMDR Therapy?
People who are dealing with traumatic memories and those who have PTSD are thought to benefit the most from EMDR therapy.
It’s thought to be particularly effective for those who struggle to talk about their past experiences.
Although there is not sufficient research to prove its effectiveness in these areas, EMDR therapy is also being used to treat:
EMDR therapy is broken down into eight different phases, so you’ll need to attend multiple sessions. Treatment usually takes about 12 separate sessions.
Phase 1: History and treatment planning
Your therapist will first review your history and decide where you are in the treatment process. This evaluation phase also includes talking about your trauma and identifying potential traumatic memories to treat specifically.
Phase 2: Preparation
Your therapist will then help you learn several different ways to cope with the emotional or psychological stress you’re experiencing.
Stress management techniques such as deep breathing and mindfulness may be used.
Phase 3: Assessment
During the third phase of EMDR treatment, your therapist will identify the specific memories that will be targeted and all the associated components (such as the physical sensations that are stimulated when you concentrate on an event) for each target memory.
Phases 4–7: Treatment
Your therapist will then begin using EMDR therapy techniques to treat your targeted memories. During these sessions, you will be asked to focus on a negative thought, memory, or image.
Your therapist will simultaneously have you do specific eye movements. The bilateral stimulation may also include taps or other movements mixed in, depending on your case.
After the bilateral stimulation, your therapist will ask you to let your mind go blank and notice the thoughts and feelings you’re having spontaneously. After you identify these thoughts, your therapist may have you refocus on that traumatic memory, or move on to another.
If you become distressed, your therapist will help bring you back to the present before moving on to another traumatic memory. Over time, the distress over particular thoughts, images, or memories should start to fade.
Phase 8: Evaluation
In the final phase, you’ll be asked to evaluate your progress after these sessions. Your therapist will do the same.
How Effective is EMDR Therapy?
Multiple independent and controlled studies have shown that EMDR therapy is an effective treatment for PTSD. It’s even one of the Department of Veterans Affairs’ strongly recommended options to treat PTSD.
A 2012 study of 22 people found that EMDR therapy helped 77 percent of the individuals with a psychotic disorder and PTSD. It found that their hallucinations, delusions, anxiety, and depression symptoms were significantly improved after treatment. The study also found that symptoms were not exacerbated during treatment.
An older study trusted Source that compared EMDR therapy to typical prolonged exposure therapy, found that EMDR therapy was more effective in treating symptoms. The study also found that EMDR therapy had a lower dropout rate from participants. Both, however, offered a reduction in the symptoms of traumatic stress, including both anxiety and depression.
Several small studies have also found evidence that EMDR therapy is not only effective in the short term but that its effects can be maintained long term. One 2004 study evaluated people several months after they were given either “standard care” (SC) treatment for PTSD or EMDR therapy.
During and immediately after treatment, they noticed that EMDR was significantly more efficient in reducing symptoms of PTSD. During the three- and six-month follow-ups, they also recognized that participants maintained these benefits long after the treatment had ended. Overall, the study found that EMDR therapy gave people a longer-lasting reduction in symptoms than SC.
EMDR therapy has proven to be effective in treating trauma and PTSD. It may also be able to help treat other mental conditions like anxiety, depression, and panic disorders.
Some people may prefer this treatment to prescription medications, which can have unexpected side effects. Others may find that EMDR therapy strengthens the effectiveness of their medications. In Kaiyan Medical, we can help you create your own EMDR therapy device.
Shapiro, F. (2014). The role of eye movement desensitization and reprocessing (EMDR) therapy in medicine: Addressing the psychological and physical symptoms stemming from adverse life experiences. DOI: 10.7812/TPP/13–098
Life without light is darkness. Light plays a vital role in our healthy life. Now the light is expanding the business scope in business for LIGHT THERAPY.
Light therapy also known as phototherapy is a simplified process, where the skin is precisely exposed before a light-emitting source on a routine. This light resembles natural light which helps to stimulate cells in the affected section.
Light Therapy has a notable history. It started back in 1903, when Niels Ryberg Finsen, developed a device that produced synthesized light. He was also awarded Nobel Prize in Medicine for this discovery. Later in 1938, a hospital in Massachusetts performed effective testing on patients with colored lights.
Light therapy at the present considered as one of the standard of care for the treatment of various diseases by most of the healthcare professionals.
According to research, the global cosmetic products market is estimated to be valued at US$ 69 billion in the year 2025. One of the emerging business amongst the beauty and medical market is LIGHT THERAPY.
Light Therapy Market size was valued at USD 811.8 million in the year 2018 and is expected to witness a rise of 4.6% CAGR from 2019 to 2025.
Drivers for the growth
The reason behind the growth of the market is driven by factors like the increase in dermatological disorders such as acne vulgaris, psoriasis, wrinkles. Light therapy market includes the usage of various lights like red, blue, green in dermatological as well as medical, health, sports industry too. The application of light therapy is vast and wide, which makes the market more diverge. It gives different companies an opportunity to participate and explore the market.
Additionally the rising disposable income, growth of upper middle-class population and increasing awareness of beauty products.
Also, modern users are more inclined towards the non-invasive treatment. With favorable reimbursement scenario in and advancement in the product technology, the liking of the light therapy has increased.
The Handheld devices for skin treatment (HDST) category held over 16.5% revenue share in 2018 and is now estimated to grow significantly by 2025. There is a wide adoption of handheld devices in home-care settings since the handheld devices have the ability to avoid the cell disruptions during light therapy treatment.
Light Therapy Market, By Product
Handheld devices for skin treatment (HDST) segment held over 16.5% revenue share in 2018 and is projected to grow significantly by 2025. Ability of handheld devices to avoid cell disruption during light therapy device placement will upsurge its adoption in noninvasive interventions. Wide adoption of handheld devices in homecare settings will thus spur segment size.
Light visor segment is projected to witness robust CAGR of more than 4% over the forthcoming years. Adoption of portable lightening units such as light visors for effective patient management will accelerate segment growth over the coming years.
Light Therapy Market, By Application
Light therapy market is evolving day by day. In the past decade, there is a significant growth in this market. The wide range of applications in health, fitness, sports, beauty and medical field has increased the interest of buyers.
Sleeping disorder market segment was valued over USD 110 million in the year 2018 and is estimated to witness a similar trend during the upcoming years. The rising prevalence of sleep disorders such as Seasonal Affective Disorder (SAD), insomnia and jet lag and will uplift this segment growth. Additionally, the rising demand for light therapy for patients suffering from circadian rhythm will amplify the adoption of light therapy in the predictable future.
Another segmentation of application is the different forms where light therapy is being used like clinics, salons, home, hospitals etc. Dermatology clinics held more than 26% revenue share in 2018 as per a report. Also, the application at home is at soar. The end-users convenience is a major reason for the home-care setting application great market value which was around USD 495 million in 2018.
Light Therapy Market, By Light Type
Blue light segment accounted for more than 26% revenue share in 2018 and will exhibit substantial growth over the coming years. Extensive adoption of blue light in the treatment of sun damage as well as premalignant or malignant skin cancer should propel segment growth.
Red light segment is anticipated to witness around 4.5% CAGR over the forthcoming years. Wide application of red-light therapy in the treatment of orthopedic conditions such as joint pain, inflammation and arthritis will surge its adoption over the coming years.
Light Therapy Market, By End-use
Dermatology clinics held more than 26% revenue share in 2018 and will exhibit momentous growth over the forecast timeline. Rising incidence of skin disorders coupled with increasing demand for non-invasive procedures will foster segment growth during the forthcoming years.
Home-care settings segment was valued around USD 495 million in 2018 due to increasing patient preference towards home-care. Benefits offered by home-care settings such as quality treatment at affordable prices and reduced risk of dermatological clinics acquired infections will fuel the business growth.
Light Therapy Market, By Region
North America light therapy market will witness over 4% CAGR over the analysis timeline. Rising prevalence of skin disorders including eczema and skin cancer in North America is key factor driving light therapy business growth. Strong foothold of key industry players in the region will positively impact industry growth.
Asia Pacific light therapy market was valued more than USD 175 million revenue in 2018. Urbanization, changing lifestyle and increasing prevalence of depression and hypertension in the region will favor regional business growth. Increasing healthcare reforms in countries such as China will further drive Asia Pacific light therapy industry growth in the coming years.
As humans, we are made of energy and fueled by light. While nutrition and exercise play a role in our well-being and health, light plays a crucial role in us functioning optimally. New and groundbreaking research is unearthing a new understanding of how our cells function and the evidence points to the power of light.
Through technological advancements in science, it’s discovered that our bodies operate similar to a battery. Wavelengths of light give us power, while our overall health determines our ability to receive and maintain the energy from light. And this is where light therapy comes into the equation.
What is Red Light Therapy
Science has proven that our bodies interact with specific wavelengths that benefit our bodies in various ways.
Red light therapy devices, such as light therapy masks, shine red and near-infrared light onto the skin, stimulating the production of adenosine triphosphate (ATP) within the mitochondria. By stimulating ATP, damaged cells heal, and new cells are produced faster than normal. But we’ll talk more about that in-depth a little later.
Red light therapy comprises both red light and infrared wavelengths, penetrating through the skin’s layers, right into the cells. Red light wavelengths boost collagen and elastin and improve cell communication. It penetrates superficially and helps aid various skin conditions.
Near-infrared wavelengths stimulate healing, increase mitochondrial function, and improve blood flow and tissue oxygenation. Near-infrared wavelengths penetrate deeply into the body.
Recharging Your Body From Within
At the core of your body’s healing capabilities are the mitochondria. The mitochondria play a vital role in your internal organs and tissue, including the liver, skin, heart, and muscles. It’s in charge of the body’s energy supply via ATP (adenosine triphosphate).
With both working together, they provide energy to our body and maintain the cell cycle and growth. This is why you’ll often hear the mitochondria referred to as the “powerhouse of the cell.”
Here's how the mitochondria is affected by red light:
LED light wavelengths from 600-800nm(red) and between 810-850nm(infrared) penetrate through the skin into the cells via a red light therapy device.
Light enters the cell's mitochondria, absorbed by chromophores which include EZ water and protein cytochrome c oxidase (CCO), resulting in stimulating activity.
Subsequently, three molecules are affected: Adenosine Triphosphate (ATP), Reactive Oxygen Species (ROS), and Nitric Oxide (NO).
Interestingly, our body weight is made of 70% water, with 99% of our bodies' molecules also made of water, making it a powerful component in red light therapy treatment.
Research by Prof Gerald Pollock of the University of Washington proved that water adjacent to a cell is structured water, also known as EZ water. This specific water forms a separation of charge, functioning in the body as positive and negative poles - similar to a battery.
What Does “Red Light Therapy” Mean?
While we’ve been talking about red light therapy, what does it actually mean? Typically, “red light therapy” refers to natural light treatments which deliver red and near-infrared wavelengths as natural sunlight using LEDs or cold lasers.
While you may think red light therapy includes all colors of light, it doesn’t. The term doesn’t include blue or white light, and it isn’t equivalent to full-spectrum light. Red light therapy doesn’t rely on heat, differentiating it from other light-based treatments such as infrared saunas and heat therapy.
Red light therapy is also known as RLT, photobiomodulation (PBM), phototherapy, LED therapy, LED light therapy, infrared therapy, low-level laser therapy, or low-level light therapy (LLLT).
Red Light Therapy: The Multilevel Treatment
As stated before, red light therapy works to heal the entire body and functions on multiple levels.
Adenosine triphosphate (ATP)
Retrograde mitochondrial signaling
Reactive oxygen species
Water, opsins, chromophores, cytochrome c oxidase
Gene transcription factors
Brain-derived neurotrophic factor
Inflammation, Cytoprotection, Proliferation
Stem cell production and migration
Immune cell viability
Retrograde mitochondrial signaling
Transforming growth factor
Pro-and anti-inflammatory cytokines
Mitochondrial membrane potential
Muscles: Increase endurance, tone density
Brain: Improves cognition and immune
Nerves: Repair and pain relief
Healing bones, tendons, and wounds
Increases hair growth
Improvement of the collagen network, anti-aging, skin disorders
Fat re-absorption improved by enhanced micro-circulation
Improved immunity and lymphatic system
Systemic Effects: Positive Affects on Bodily Systems
Red light therapy affects the body in multiple ways, including bodily systems:
Fascia is the thin casing of connective tissue that surrounds virtually every organ, muscle, nerve fiber, blood vessel, and bone in place. While it performs as an internal structure for your body, the fascia also contains nerves, making it almost as sensitive as skin.
The fascia may look like a layer of tissue; however, it’s made up of interwoven layers of collagen and elastin fibers. The fascia is overlooked, yet over recent years, it has been the key to understanding how changes in one area of our body affect others. Red light therapy works to improve communication within the fascia network.
The gut-brain axis connects the emotional and cognitive centers of the brain with peripheral intestinal functions. Recent research discovered the importance of gut microbiota concerning these interactions.
Red light therapy can positively influence mood and neuropsychological issues by the following:
Reducing gut spasms and bowel inflammation.
Increasing neurotransmitters, activating the brain’s immune system, thus increasing blood flow and eliminating toxins.
Reduce blood pressure and increase circulation to eliminate brain fog and anxiety.
Changes the vagus nerve, which connects the gut and brain. It plays a role in stress and social communication.
Changes of the micro-biome.
Red and near-infrared light penetrate through the skin into the cells, which results in low-dose metabolic stress that strengthens the cells’ anti-inflammatory and natural defense systems. In turn, the body becomes resilient to infections.
Safe and low exposure to red light therapy improves the body’s response to external viruses and bacteria. Red light therapy can influence the immune response in the following ways:
Enhances proliferation, maturation, and motility of fibroblasts.
Activates macrophages to behave as phagocytes.
Increases production of fibroblast growth.
Proliferation and activation of lymphocytes.
Release of pro-inflammatory cytokines and mast cell degranulation.
Activation of mast cells results in reduced inflammation.
Red light therapy is scientifically proven to increase the micro-circulation of blood and support the circulatory system as a whole by stimulating the development of new capillaries which carry oxygen throughout the body.
Proper oxygen supply and flow are essential for the proliferation of cells, protein synthesis, tissue restoration, inflammatory response, and angiogenesis. In addition, circulation is also responsible for waste elimination, specifically degenerated cells.
The nervous system includes the brain, spinal cord, neurons, and neural support cells, which is your body’s command center. It controls your movements, automatic responses, and other body systems such as digestion and breathing.
Red light therapy affects the nervous system in the following ways:
Releases growth factors.
Increases the vascular network and collagen.
Facilitates neural regeneration.
Regenerates the nerve lesions and damaged nerves at a faster rate.
Improves the electrophysiological function.
Myelination of fibers.
For all forms of nerve damage, red light therapy offers non-pharmaceutical treatment options.
Red light therapy shows impressive results regarding stem cell growth, maximizing the potential of stem cell implantation for various medical needs. Therefore, red light therapy may show positive results after surgery to stimulate stem cells which repair tissues and organs.
In studies, red light therapy has proven to stimulate mesenchymal stem cells in bone marrow, enhancing their ability to reach the brain. This research shows the possibilities of using red light therapy to heal degenerative conditions, including Alzheimer’s, Parkinson’s disease, and dementia.
The Origins of Modern Red Light Therapy
It’s clear red light therapy provides multilevel treatment to the body, becoming a popular natural and holistic option for both professionals and consumers, but where did it come from?
Light therapy technology isn’t new; it’s been around for decades as NASA experimented with red light therapy during the 1980s and 1990s. Over the past 10-20 years, red light therapy reached a breakthrough in LED lighting technology, allowing the production of safe and affordable clinical and at-home devices.
We mentioned red light therapy being a holistic treatment option, but what does that mean. Holistic medicine is a full-body approach to healthcare. By focusing on the body, mind, and soul, the body receives the full support and care it needs to function optimally.
Principles of Holistic Medicine
Holistic medicine is based on the following principles:
Optimal health is the combination of emotional, mental, spiritual, social and physical wellness.
The focus is to prevent first, and treat second.
The disease or illness is not caused by a single area, rather the whole body.
The purpose of treatment is to identify the underlying cause of the disease, rather than treating only the symptoms.
6 Main Benefits from Red Light Therapy
While there are endless benefits the body receives from red light therapy, here are the six main benefits.
Relieves Pain And Discomfort
Photobiomodulation, in other words, red light therapy, has proven effective against carpal tunnel syndrome, mucositis, neck pain, menstrual cramps, temporomandibular joint pain, and neuropathic pain from amputation. It also significantly reduces the pain of hypersensitivity while improving sensorimotor function.
These improvements come after anti-inflammatory cells populate the injured area, providing long-lasting pain relief. In addition, it’s also been shown to provide effective relief by affecting the following:
Represses cyclooxygenase and prostaglandins.
Activating peripheral opioid receptors.
Increasing endorphins serotonin release.
Stimulates the metabolism.
Changes nerve transmission.
Red light therapy has proven to be highly effective in rapidly treating wounds from burns, scars, bedsores, ulcers, surgery incisions, and diabetic neuropathy.
NASA strongly supports this claim as this technology was used in treating wounds. Red and near-infrared light proves effective in all four phases of the wound-healing process:
These processes are regulated by various factors connected via nitric oxide (NO) signaling release, adjusted by light energy.
An issue the body encounters when trying to heal a wound is low oxygen flow, and red light increases the flow of oxygen, speeding up the natural healing process. By reducing inflammation and increasing oxygenation of the wounded area, blood vessels can form, rapidly repairing the area, lessening pain and scarring.
By reducing pain, red light therapy eliminates the reliant on pharmaceutical painkillers during the healing process.
The human body receives energy on the cellular level, maintaining communication between organs and ensuring disease resistance.
A strong immune system works to protect the body from harmful bacteria and viruses at all times. With red light therapy, the body receives a boost of support as it releases nitric oxide and melatonin, two components involved in DNA repair and antimicrobial.
This process is called hormesis. Red and near-infrared wavelengths penetrate through the skin into the cells, causing mild metabolic stress, which stimulates cells to activate their anti-inflammatory and antioxidant response.
With the support of red light therapy, the body is better prepared to fight infections. Numerous studies have proven red light therapy to have the following effects on the immune system:
Improves melatonin production
Increases NO levels
Improves antioxidant production
Improves thyroid function
Stimulates T cells pre-operatively
Increases flow of neurotransmitters
Boosts collagen and elastin production
Encourages lymph node activity
Enables the transportation of immune cells
Stimulates optimal function of cells and organelles
Inflammation in the body can be acute and topical (short-term, resulting from sprains, infections, and accidents) or chronic and general (long-term, caused by ongoing conditions).
Acute inflammation is a healthy bodily response; however, chronic and general inflammation can negatively impact long-term health.
As of today, the current treatment for inflammation is NSAID or steroid drugs, both having a detrimental effect on the healing process and long-term health. Red light therapy stimulates the body to activate its natural healing mechanism, reducing the health risks of long-term drug use.
Red light therapy decreases the number of inflammatory cells, increases fibroblast proliferation (cells that synthesize collagen and other matrix macromolecules), stimulates angiogenesis (creation of new blood vessels), and activates the body’s anti-inflammatory, antioxidant response.
The following conditions are connected with chronic and acute inflammation, all proving promising results with red light therapy treatment:
Neuron inflammatory disorders such as Alzheimer’s
Irritable bowel syndrome and colitis
Red light therapy is extremely popular in competitive sports and performance. It offers natural and non-pharmaceutical treatment, which applies to many areas of the body.
Aside from the overwhelming benefits on overall health, red light therapy encourages muscles growth and repair by stimulating the production of ATP, which aids in faster recovery and better performance.
Red light therapy used before training prepares and strengthens the body while aiding muscle recovery after training.
Here are the scientifically documented effects of red light therapy:
Reducing DOMS (Delayed Onset Muscle Soreness)
Enhanced endurance and performance
Increasing sleep quality
Improving sexual function and libido (including Testosterone)
Aiding weight loss
Boosting cognitive function
Reversing skin aging
Reduces symptoms of depression and seasonal affective disorder
Seasonal affective disorder (SAD) is a form of depressions, impacting 5% of Americans, specifically during the winter when there’s less natural sunlight. SAD is also known as seasonal depression or winter blues.
Many people treat SAD symptoms via bright white light treatment, mimicking the sun’s light daily. However, researchers recommend natural light treatment, like red light therapy, to help with light deficiency. Over recent years, physicians recommend red light therapy alongside psychotherapy and medication.
Who Can Use Red Light Therapy?
While many people are using red light therapy devices for at-home treatment, red light therapy systems are found in many clinical and professional settings:
Skincare Professionals: Red light therapy is a popular skincare treatment among Hollywood celebrities, including Kourtney Kardashian, Julia Roberts, and Emma Stone. Leading skincare professionals like dermatologists and aestheticians use red light therapy to help promote collagen production, reduce wrinkles, and treat skin conditions.
Health Practitioners: Health practitioners from all specialties are incorporating red light therapy into their practice. Dentists use it to reduce inflammation, physicians for mental health conditions, and oncologists for cancer side effects.
Natural Health Experts: Leading voices in the health and wellness industry such as Dr. Sarah Ballantyne, Ben Greenfield, and Dave Asprey strongly support the use of red light therapy. Paleo and Keto health experts like Robb Wolf, Mark Sisson, Luke Story, and Dr. Anthony Gustin also support red light therapy.
Sports Medicine Pros: The National Sports Association of Sports Medicine (NASM) adopted red light therapy to treat sports injuries. Top trainers and doctors, including Dr. Troy Van Biezen and Dr. Ara Suppiah, use red light therapy to heal their athletes.
Elite Pro Athletes: Professional athletes worldwide, including NFL stars like Patrick Peterson, UFC champion Anthony Pettis, and gold medal gymnast Sanne Weavers use red light therapy to enhance performance and quicken recovery.
Fitness & Training: World-renown fitness trainers, including Lacey Stone and Jorge Cruise, use red light therapy to enhance athletic performance and muscle recovery.
Supportive Cancer Care: The Multinational Association of Supportive Care in Cancer (MASCC) recommends the treatment of red light therapy for oral mucositis (OM), a common symptom of cancer treatment.
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Liu KH, Liu D, et al. “Comparative effectiveness of low-level laser therapy for adult androgenic alopecia: a system review and meta-analysis of randomized controlled trials.” Lasers in Medical Science. 2019 Aug.
Gupta AK, Mays RR, et al. “Efficacy of non-surgical treatments for androgenetic alopecia: a systematic review and network meta-analysis.” JEADV. 2018 Dec.
Afifi L, Maranda EL, et al. “Low-level laser therapy as a treatment for androgenetic alopecia.” Lasers in Surgery and Medicine. 2017 Jan.
Hofling DB, Chavantes MC, et al. Low-level laser in the treatment of patients with hypothyroidism induced by chronic autoimmune thyroiditis: a randomized, placebo-controlled clinical trial. Lasers in Surgery and Medicine. May 2013.
Hofling DB, Chavantes MC, et al. Assessment of the effects of low-level laser therapy on the thyroid vascularization of patients with autoimmune hypothyroidism by color Doppler ultrasound. ISRN Endocrinology. 2012.
Hofling DB, Chavantes MC, et al. Low-level laser therapy in chronic autoimmune thyroiditis: a pilot study. Lasers in Surgery and Medicine. 2010 Aug.
Vladimirovich Moskvin S., Ivanovich Apolikhin O. Effectiveness of low level laser therapy for treating male infertility. Biomedicine (Taipei). 2018 June.
Ban Frangez H., Frangez I., Verdenik I., Jansa V., Virant Klun I. Photobiomodulation with light-emitting diodes improves sperm motility in men with asthenozoospermia. Laser in Medical Science, 2015 Jan.
Salman Yazdi, R., Bakhshi, S., Jannat Alipoor, F. et al. Effect of 830-nm diode laser irradiation on human sperm motility. Lasers Med Sci. 2014.
Chow KW, Preece D, Burns MW. Effect of red light on optically trapped spermatozoa. Biomedical Optics Express. 2017 Aug.
Preece D., Chow KW, Gomez-Godinez V., Gustafson K., et al. Red light improves spermatozoa motility and does not induce oxidative DNA damage. Scientific Reports. 2017 Apr.
American Psychiatric Association
Cassano P, Petrie SR, et al. Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomedicine and Laser Surgery. 2018 October.
Barrett DW, et al. Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans. 2013 Jan.
Blanco NJ, Maddox WT, Gonzalez-Lima F. Improving executive function using transcranial infrared laser stimulation. Journal of Neuropsychology. 2017 Mar.
Paolillo FR, Borghi-Silva A, et al. New treatment of cellulite with infrared-LED illumination applied during high-intensity treadmill training. J Cosmet Laser Ther. 2011 Aug;13(4):166-71.
Caruso-Davis MK, Guillot TS, Podichetty VK, Mashtalir N, Dhurandhar NV, Dubuisson O, Yu Y. Efficacy of low-level laser therapy for body contouring and spot fat reduction. Obes Surg. 2011. Jun;21(6):722-9.
Jackson RF, Dedo DD, Roche GC, et al. Low-level laser therapy as a non-invasive approach for body contouring: a randomized, controlled study. Lasers in Surgery and Medicine. Dec 2009;41(10):99-809.
McRae E and Boris J. Independent evaluation of low-level laser therapy at 635 nm for non-invasive body contouring of the waist, hips, and thighs. Lasers in Surgery and Medicine. Jan 2013.
Avci P, Gupta A, et al. Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring. Seminars in Cutaneous Medicine and Surgery. Mar 2013; 32(1): 41-52.
Wouldn’t it be great if we could each reduce a couple of inches off our waist without having to diet or exercise for so long? Losing weight and fat is one of the most common health goals, both for medical and cosmetic reasons. For years, millions of people have tried different pills, injections, “natural” herbs, and many products that are supposed to help us reduce weight. Unfortunately, these usually don’t work
Many people trying to lose weight just want to look better in the mirror, or at the beach. A wide variety of therapies to target fat and improve appearance are called “body contouring” or “body sculpting”, some surgical, others noninvasive. But many of them don’t work, or produce troublesome side effects. Green light therapy is completely natural & noninvasive and has proven to be an effective option for changing the way your body looks.
In the clinical trial NCT03647748 a double-blind, placebo-controlled randomized evaluation of the effect of Cellulize, a green light low-level laser system for aesthetic use for the non-invasive reduction in fat layer for body contouring and reduction of cellulite.
The Cellulize is a non-invasive green light system with a power output of 105mW/cm2, consisting of 150 light-emitting diodes (LEDs) that emit visible light at a nominal wavelength of 532nm ± 3nm (visible green light spectrum) and a spectral bandwidth of 10nm. Cellulize® is indicated for uses non-invasive dermatological aesthetic treatment for the reduction of circumference of hips, waist, and thighs. The Massager component is indicated for the temporary reduction in the appearance of cellulite.
Cumulative circumferences of waist, hip, left and right thighs for each patient was calculated before and after treatment. Three main points were concluded as a result of the study:
1. Cellulize causes immediate inch loss in subjects after a regimen of six treatments of 32 minutes (8 minutes on each of four positions) compared to individuals subjected to a placebo device for equivalent treatment. In a typical regimen, patients lost an average cumulative of 2.67 inches of circumference compared to the placebo average of 0.5 inches. This meets the anticipated primary outcome measure “Average Change in Inches of Total Circumference Measurements for the effect of Cellulize, a LED 532nm green light low-level laser system for aesthetic use for the non-invasive reduction in fat layer for body contouring from baseline measurements, and after treatment. ”
Figure 1, below, shows the graphical summary of inch loss for patients in the Cellulize active group and the Placebo control group respectively. Table 1 gives the mean values for both groups as well as the standard deviation for the “after” measurements, as well as 7-day and 14-day follow-ups relative to the “before” measurements for each patient:
2. While the durability of effect is also impacted by extrinsic factors after treatments such as diet, it was demonstrated that subjects were more likely to show continued inch loss upon following up with each subject at 7 days and again at 14 days. In general, patients undergoing active Cellulize 532nm green light continued losing some inch with an average continued loss of an additional 1.20 inches for a total average inch loss of 3.87 inches where average placebo measurements after 14 days yielded a net gain (not a loss) of 0.875 inches. This implies that the green light treatment meets the expected primary outcome of demonstrated durability of effect after a short -term follows up of 2 weeks.
3 Finally, the effect of Cellulize LED 532nm green light without any other intervention was measured for its effect on cellulite as part of the study. The Nurnberger-Muller Scale (NMS), a four-stage scale used as an industry standard to classify stage or degree of cellulite and to determine the change in stage or degree of cellulite following treatment intervention, was used to ensure consistent evaluation standards. Results from the active device as well as placebo both showed that cellulite, in general, did not decrease on the back of thigh/buttocks for subjects after a single treatment of 532nm green light. This result failed to meet the anticipated primary outcome measure of decreasing the appearance of cellulite as a measure of the Nurnberger-Muller Scale (NMS) from baseline to completion of treatment for the thigh/buttock area.
Fat Reducing Low-Level Laser — OLI
The FDA product classification code, OLI, has a guidance document which is the special control for this product, Guidance for Industry and FDA Staff — Class II Special Controls Guidance Document: Low-Level Laser System for Aesthetic Use. According to the guidance document, FDA believes that special controls, when combined with the general controls, will be sufficient to provide reasonable assurance of the safety and effectiveness of the low-level laser system for aesthetic use. Cellulize complies with all of the standards outlined in the special controls consensus standards.
Duarte FO, et al. Can low-level laser therapy (LLLT) associated with an aerobic plus resistance training change the cardiometabolic risk in obese women? A placebo-controlled clinical trial. J Photochem Photobiol B. 2015 Dec;153:103–10.
da Silveira Campos RM, Dâmaso AR, et al. The effects of exercise training associated with low-level laser therapy on biomarkers of adipose tissue transdifferentiation in obese women. Lasers in Medical Science. 2018 Aug;33(6):1245–1254.
Due COVID, everyone is obsessed with skin care these days, regular at-home routines have really leveled up, and no skin-care gadget is as intriguing as the LED light-therapy mask.
Celebrities are no longer the only ones who get to wear luminescent masks and haunt the public’s dreams by instagramming their LED selfies. There are now several regular-person versions available online, meaning anyone can harness the power of LED light, the green light for pain relief and slimming, the blue for bacteria-killing and red for collagen- and elastin-stimulating.
In Kaiyan Medical, we can create your FDA cleared light therapy mask based on your needs and market.
Here the top light therapy masks
MZ Skin Light-Therapy Golden Facial Treatment Device
If your skin is temperamental, it’s nice to have a well-rounded, high-performance mask on call. Designed to replicate MZ skin founder Dr. Maryam Zamani’s in-office treatments, it comes with five different light settings (red, blue, green, yellow, and white) so you can focus on anything from inflamed breakouts to the annoying scars and discoloration those pimples sometimes leave in their wake.
Using this mask you can actually see out of it without lines obstructing your view. It’s designed to be very wearable and on-the-go, so you can continue doing whatever you’re doing while treating your skin. The Light Shield allows the wearer to enjoy RED, BLUE, and AMBER LED therapies. Specifically target post-treatment/facial redness with RED light, shown to boost circulation and speed healing
Project E Beauty Wireless LED Light Skin Rejuvenation Therapy Mask
This mask comes with seven different light colors to treat every skin-care issue imaginable on the face. Project E’s mask goes a step further with a bonus attachment for the neck, arguably the most overlooked part of skin-care routines. 99 + 40 LED lights cover your face & neck, upgraded to emit the most optimal wavelengths with 5 levels of intensity.
If you’re a K-beauty fan, there’s a Korean LED face mask just for you! This one comes from LG. All that appliance expertise has been channeled into a mask that hits the skin with red and infrared LED light in quick, nine-minute sessions focused on improving skin elasticity and brightness.
Dr. Dennis Gross Skin-Care SpectraLite Faceware Pro
Average price: $435
This LED mask from Dr. Dennis Gross is one of the more fashionable ones on the market. It comes with gold accents, 162 LED lights, and three treatment options to choose from: red-light therapy, blue-light therapy, or red and blue–light therapy.
TOP #1 — ADURO ® 7+1 LED FACE MASK
Do you value personal comfort while lurking and skulking? This soft, silicone mask is less hockey goalie and more like an actual face mask that molds to your face shape for a more comfortable treatment. The aduro mask is the most advanced home-use facial mask based on light therapy.